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OCR: oice 1s In the UK and Europe, the drug of first tion of carbimazole, which blocks the organific mation of iodine in the thyroid and reduces the fo effect on new thyroid hormone, while having n le, Two the release of preformed thyroid hormo roid alternative regimens are used for antith d with a therapy. In both, treatment is commen g three large dose - for example carbimazole 15 cally times daily - and when the patient is cli eks, the euthyroid, usually within six to eight w ure, the strategies differ, In the traditional proce ist the dose is rapidly reduced to be titrated aga Rto clinical and biochemical response, aimi iven once achieve a maintenance dose of 10-15mg en, the daily. In the blocking-replacement regi .1mg or high initial dose is maintained, and T4, 0.15mg daily, is added,